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Human Organoid-based Gut Evaluation Services

Human intestinal organoid-based solutions for drug efficacy and gut barrier assessment

Moving beyond the limitations of conventional 2D cell cultures and animal models, our human intestinal organoid platform enables more physiologically relevant evaluation of drug efficacy, gut barrier function, absorption, and microbiome interactions.
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Why ODISEI GUT?

Generate more reliable research data with human-relevant intestinal biology.

Cell Composition Validation

Reproduces diverse intestinal epithelial cell populations to reflect human intestinal cell diversity.

Functional Validation

Validates physiological intestinal epithelial function through the forskolin-induced swelling assay.

Tissue-Level Validation

Confirms key structural characteristics of intestinal tissue through cell-specific marker expression.

Why Are Conventional Evaluation Models Not Enough?

A more human-relevant intestinal environment enables more reliable research data.

2D Cell Cultures

  • Lack of 3D intestinal architecture
  • Limited epithelial cell diversity
  • Limited assessment of gut barrier function
Abstract teal circular arcs forming a partial ring on a black background.

ODISEI GUT

  • Human-relevant intestinal architecture
  • Diverse intestinal epithelial cell populations
  • Functional gut barrier modeling
  • IBD & Leaky Gut disease models
  • Enhanced human predictivity

Animal Models

  • Physiological differences from humans
  • Limited predictability of human drug responses
  • Limited clinical translatability

What Can You Evaluate?

Comprehensively evaluate drug efficacy, gut function, absorption, and microbiome interactions using human intestinal organoids.
  • Drug Efficacy Assessment
  • Gut Barrier Function Assessment
  • Drug Absorption & Permeability
  • Microbiome & Probiotics Assessment
  • Intestinal Disease Modeling
  • Intestinal Toxicity Assessment

What Intestinal Diseases Can Be Modeled?

Model human intestinal diseases using organoids to evaluate drug responses and recovery effects.

01Inflammatory Bowel Disease (IBD)

Recreates an inflammatory intestinal environment using pro-inflammatory cytokines to evaluate the anti-inflammatory and gut barrier recovery effects of candidate compounds.

✓ Key Assessments

  • Changes in inflammatory cytokine secretion
  • Tight junction protein expression, including ZO-1 and Occludin
  • Intestinal permeability & barrier recovery

IBD(Inflammatory Bowel Disease) Model

02Leaky Gut Syndrome (LGS)

Recreates gut barrier disruption and increased permeability to evaluate the protective and recovery effects of candidate compounds.

✓ Key Assessments

  • FITC-Dextran permeability assay
  • Mucin layer & tight junction integrity
  • Gut barrier protection & recovery

LGS(Leaky Gut Syndrome) Model

Evaluate Multiple Intestinal Functions on a Single Platform

From gut barrier function to drug absorption and microbiome interactions, evaluate multiple intestinal functions in a human-relevant environment.

Gut Barrier Function & Recovery

Quantitatively evaluate gut barrier damage, permeability, and recovery.

  • Transepithelial Electrical Resistance (TEER)
  • FITC-Dextran Permeability
  • Tight Junction Protein Expression
  • Mucin Layer Formation
FITC-Dextran Permeability Analysis

Drug Absorption & Permeability

Evaluate drug absorption, permeability, and metabolism using human intestinal epithelium.

  • Drug Absorption & Apparent Permeability (Papp)
  • FITC-Dextran Permeability
  • Drug Metabolic Stability
  • Human Absorption Predictivity
Comparative Analysis of Drug Permeability (Papp)

Microbiome & Probiotics

Evaluate functional materials by analyzing microbial adhesion and interactions with the intestinal epithelium.

  • Microbial Adhesion to Intestinal Epithelium
  • Host-Microbiome Interaction
  • Probiotic Efficacy
Microbial Adhesion Analysis in Intestinal Epithelial Cells

Assess Efficacy Through Multiple Functional Readouts

Evaluate candidate efficacy and mechanisms of action using functional assays tailored to your research objectives.
  • TEER Analysis
  • Intestinal Permeability Analysis
  • Swelling Assay
  • Immunofluorescence Analysis
  • Cytokine Analysis
  • Live-Cell Imaging

Live Imaging Example

Normal Control
Intestinal organoid
Disease Model (LGS)
LGS induced model
Drug-treated Model
Drug treated in LGS model

Assess Efficacy Through Multiple Functional Readouts

Evaluate candidate efficacy and mechanisms of action using functional assays tailored to your research objectives.

Research-Validated Human Intestinal Epithelial Model

A study published in Science Advances validated the physiological characteristics of human small intestinal epithelium and its applicability to drug absorption assessment.

Relevant Drug Absorption Prediction

Overcoming the limitations of conventional Caco-2 models, our platform reflects human intestinal drug absorption and first-pass metabolism.

Standardized Evaluation Protocols

Standardized protocols have been established for intestinal epithelial cell differentiation, drug absorption, and microbial interaction assessment.

Generate More Reliable Research Data with Human Intestinal Organoids

Discover evaluation services tailored to your research objectives.
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ORGANOIDSCIENCES

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